Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cervical carcinoma: an experimental approach.

M E Cowan1, G R Skinner

  • 1Department of Medical Microbiology, University of Birmingham, UK.

Cancer Surveys
|January 1, 1988
PubMed
Summary

This study explored a herpes simplex virus (HSV) vaccine

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuroendocrine regulation of reproduction in Atlantic cod (Gadus morhua): Evidence of Eya3 as an integrator of photoperiodic cues and nutritional regulation to initiate sexual maturation.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology·2021
Same author

The infrequency of transmission of herpesviruses between humans and animals; postulation of an unrecognised protective host mechanism.

Comparative immunology, microbiology and infectious diseases·2001
Same author

Prophylaxis against staphylococcal infection before tertiary knee joint replacement.

Orthopedics·2001
Same author

Prevention of herpes genitalis by the 'Bulgarian' vaccine F.HSV-2V(PRK): preliminary clinical evidence.

Croatian medical journal·2000
Same author

Efficacy of an inactivated vaccine for equine herpesvirus type 1 in a novel hamster model.

Intervirology·2000
Same author

Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.

Liver·2000

Area of Science:

  • Virology and Immunology
  • Oncology
  • Vaccine Development

Background:

  • Cervical carcinoma is a significant global health concern.
  • Herpes simplex virus type 2 (HSV-2) is a known risk factor for cervical cancer.
  • Preventive strategies, including vaccination, are crucial for combating HSV-2-associated malignancies.

Purpose of the Study:

  • To evaluate the preventive efficacy of a subunit herpes simplex virus (HSV) vaccine.
  • To assess the vaccine's impact on the development of HSV-induced cervical carcinoma in a mouse model.
  • To determine if repeated exposure to inactivated HSV-2 could induce cervical tumors.

Main Methods:

  • A mouse model was utilized for the investigation.
  • Ten groups of mice were vaccinated with a subunit HSV vaccine.
  • Mice received repeated intravaginal exposure to UV-inactivated HSV-2.
  • Histological examination of cervices was performed at 20 months postvaccination.

Main Results:

  • Neutralizing antibody activity against HSV was detected in mice receiving the highest vaccine dose.
  • A low incidence of cervical tumors and preinvasive changes was observed across experimental and control groups.
  • The majority of cervices (87%) showed normal or koilocytotic appearance upon histological examination.

Conclusions:

  • The study found no evidence that repeated exposure to inactivated HSV-2 significantly increased the incidence of preinvasive or invasive cervical carcinoma.
  • The subunit HSV vaccine demonstrated potential for inducing neutralizing antibodies.
  • Further research is warranted to explore the long-term efficacy and potential of HSV vaccines in preventing cervical cancer.

Related Experiment Videos