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Elevated Cardiovascular Risks among Postmenopausal Women: A Community Based Case Control Study from Nepal
Bashu Dev Pardhe1, Sumitra Ghimire1, Jyotsna Shakya1
1Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal.
Biochemistry Research International
|May 26, 2017
Summary
Menopause significantly increases lipid levels, raising cardiovascular disease (CVD) risk in women. Postmenopausal women exhibit higher Total Cholesterol, Triacylglycerol, HDL-C, and LDL-C, necessitating regular monitoring for dyslipidemia.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Public Health
Background:
- Cardiovascular disease (CVD) is a leading global cause of mortality, disproportionately affecting women post-menopause.
- Menopause-induced hormonal shifts contribute to dyslipidemic patterns, increasing CVD risk and complications.
- Understanding lipid profile changes during menopause is crucial for preventative healthcare strategies.
Purpose of the Study:
- To compare the lipid profiles of premenopausal and postmenopausal women.
- To investigate the relationship between Body Mass Index (BMI) and lipid parameters in both groups.
- To assess the implications of observed lipid changes for future CVD risk.
Main Methods:
- A descriptive cross-sectional study involving 260 healthy women (130 premenopausal, 130 postmenopausal).
- Fasting blood samples analyzed for Total Cholesterol (TC), Triacylglycerol (TAG), High Density Lipoprotein Cholesterol (HDL-C), and Low Density Lipoprotein Cholesterol (LDL-C).
- Statistical analysis performed using a semi-auto analyzer (Stat Fax 3300).
Main Results:
- Postmenopausal women showed significantly higher TC, TAG, HDL-C, and LDL-C compared to premenopausal women.
- The LDL/HDL ratio was significantly elevated in postmenopausal women.
- BMI correlated positively with TC and TAG in both groups, and with HDL-C in premenopausal women, but negatively in postmenopausal women.
Conclusions:
- Postmenopausal women exhibit significantly higher atherogenic lipid parameters, indicating increased susceptibility to CVD.
- The elevated LDL/HDL ratio in postmenopausal women is a critical indicator of heightened cardiovascular risk.
- Regular monitoring and management of dyslipidemia are essential for all women undergoing menopause to mitigate future CVD complications.
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