Related Experiment Video
Updated: Mar 1, 2026

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Contrast-induced acute kidney injury: A review of practical points
Sercin Ozkok1, Abdullah Ozkok1
1Sercin Ozkok, Department of Radiology, Istanbul Medeniyet University, Goztepe Training and Research Hospital, 34760 Kadikoy, Istanbul, Turkey.
Insights
Contrast-induced acute kidney injury (CI-AKI) is a common complication impacting patient health. This review covers CI-AKI causes, risks, and prevention, emphasizing updated clinical knowledge for better patient outcomes.
Area of Science:
- Nephrology
- Radiology
- Clinical Medicine
Background:
- Contrast-induced acute kidney injury (CI-AKI) is a frequent cause of acute kidney injury (AKI).
- CI-AKI is linked to increased patient morbidity and mortality.
- CI-AKI can lead to irreversible kidney damage and chronic kidney disease.
Purpose of the Study:
- To review current knowledge on CI-AKI.
- To discuss contrast media's impact on nephrotoxicity.
- To explore CI-AKI risk factors and prevention strategies.
Main Methods:
- Literature review of CI-AKI.
- Analysis of contrast media and nephrotoxicity.
- Evaluation of pathophysiological mechanisms.
- Review of preventive strategies and alternative imaging.
Main Results:
- CI-AKI is a significant clinical concern with multifactorial causes.
- Understanding pathophysiological mechanisms is crucial for prevention.
- Various risk factors contribute to CI-AKI development.
- Preventive strategies and alternative imaging methods are discussed.
Conclusions:
- CI-AKI requires ongoing clinical attention and updated knowledge.
- Effective prevention strategies are essential to mitigate patient risk.
- Further research into CI-AKI pathophysiology and management is warranted.
Abstract:
Contrast-induced acute kidney injury (CI-AKI) is one of the most common causes of AKI in clinical practice. CI-AKI has been found to be strongly associated with morbidity and mortality of the patients. Furthermore, CI-AKI may not be always reversible and it may be associated with the development of chronic kidney disease. Pathophysiology of CI-AKI is not exactly understood and there is no consensus on the preventive strategies. CI-AKI is an active research area thus clinicians should be updated periodically about this topic. In this review, we aimed to discuss the indications of contrast-enhanced imaging, types of contrast media and their impact on nephrotoxicity, major pathophysiological mechanisms, risk factors and preventive strategies of CI-AKI and alternative non-contrast-enhanced imaging methods.
Related Concept Videos
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Acute Kidney Injury I: Introduction
Acute Kidney Injury V: Interprofessional Care
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury VI: Nursing Management
Acute Kidney Injury III: Clinical Manifestations

