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Related Experiment Video

Updated: Mar 1, 2026

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
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[Intestinal microbiota in individualized therapies].

T Witte1, D H Pieper2,3, B Heidrich4

  • 1Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Deutschland.

Der Internist
|May 26, 2017
PubMed
Summary
This summary is machine-generated.

The human microbiome plays a key role in health and disease. Understanding its composition and function can lead to targeted therapies, including microbiome modification for treating conditions like Clostridium difficile infections.

Keywords:
Clostridium difficileDysbiosisFecal microbiota transplantationPrebioticsProbiotics

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Area of Science:

  • Microbiology
  • Genomics
  • Immunology

Background:

  • The human microbiota, comprising trillions of microorganisms, is increasingly recognized for its profound impact on health.
  • Dysbiosis, an imbalance in microbial communities, is linked to various diseases, including autoimmune and metabolic disorders.
  • Advanced sequencing technologies have revolutionized our ability to study microbial communities without culture-based methods.

Purpose of the Study:

  • To highlight the growing importance of human microbiota research.
  • To emphasize the potential of microbiome-targeted therapies for disease management.
  • To discuss factors influencing microbiota composition and therapeutic interventions.

Main Methods:

  • Deep sequencing analysis for comprehensive characterization of microbial communities.
  • Review of existing human and animal model studies linking microbiome to disease.
  • Analysis of therapeutic strategies such as diet, probiotics, prebiotics, and fecal microbiome transfer.

Main Results:

  • Deep sequencing provides extensive data on microbial communities.
  • The microbiome is implicated in the pathogenesis of autoimmune and metabolic diseases.
  • Fecal microbiome transfer is a clinically validated therapy for recurrent Clostridium difficile infections.

Conclusions:

  • Understanding the human microbiome is crucial for developing novel therapeutic strategies.
  • Targeting the microbiome offers potential for individualized treatment approaches.
  • Modulating the gut microbiota, through methods like fecal microbiome transfer, can lead to lasting health benefits.