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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cell-mediated Immune Responses01:40

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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Updated: Mar 1, 2026

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Cell-Based Therapies with T Regulatory Cells.

Mateusz Gliwiński1, Dorota Iwaszkiewicz-Grześ1, Piotr Trzonkowski2

  • 1Department of Clinical Immunology and Transplantology, Medical University of Gdańsk, Dębinki 7, 80-210, Gdańsk, Poland.

Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
|May 26, 2017
PubMed
Summary

T regulatory cells (Tregs) show therapeutic potential for immune-mediated diseases. Clinical trials are advancing Treg cell therapy for transplantation and autoimmunity, offering hope for incurable conditions.

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Area of Science:

  • Immunology
  • Cell Therapy

Background:

  • T regulatory cells (Tregs) are key immune suppressors.
  • Preclinical studies highlight Treg potential in immune-mediated diseases.

Purpose of the Study:

  • To review basic and clinical Treg experiences.
  • To discuss Treg adoptive transfer in clinical trials.
  • To explore future clinical applications and challenges.

Main Methods:

  • Review of preclinical data.
  • Analysis of completed and ongoing clinical trials.
  • Discussion of regulatory and technical aspects.

Main Results:

  • Tregs are being translated into clinical cell therapy.
  • Clinical trials focus on transplantation and autoimmunity.
  • Treg therapy is evolving despite challenges.

Conclusions:

  • Treg adoptive transfer is a promising cell therapy.
  • Further development is needed to overcome technical and regulatory hurdles.
  • Treg therapy may offer new options for incurable diseases.