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Updated: Mar 1, 2026

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Assessment of renal function in Indian patients with sickle cell disease

Bhaskar V K S Lakkakula1, Henu Kumar Verma1, Mona Choubey2

  • 1Research Division, Sickle Cell Institute Chhattisgarh, Raipur, Chhattisgarh, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|May 26, 2017
PubMed

Insights

Sickle cell disease (SCD) patients often experience kidney damage. This study found glomerular hyperfiltration and renal insufficiency are key indicators of kidney damage in SCD patients in India.

Area of Science:

  • Nephrology
  • Hematology
  • Genetics

Background:

  • Sickle cell disease (SCD) is a genetic blood disorder with frequent, early-onset renal complications.
  • Kidney damage in SCD progresses over time, leading to severe health issues.

Purpose of the Study:

  • To compare various creatinine-based estimated glomerular filtration rate (eGFR) equations in SCD patients.
  • To analyze the prevalence of different kidney function stages (glomerular hyperfiltration, renal insufficiency, renal failure) in SCD.
  • To correlate kidney function stages with clinical and hematological variables in SCD.

Main Methods:

  • Evaluated 616 SCD patients (HbSS and HbSB+) using MDRD, Cockcroft-Gault, CKD-EPI, Schwartz, and JSCCS-GFR equations.
  • Classified kidney function stages based on CKD-EPI and Schwartz eGFR.
  • Compared eGFR results and analyzed clinical/hematological data across kidney function stages.

Main Results:

  • MDRD and JSCCS formulas overestimated GFR in SCD patients.
  • High prevalence of glomerular hyperfiltration (GHF) and renal insufficiency (RI) observed.
  • No significant hematological differences across kidney function stages, except higher blood urea and fetal hemoglobin in renal failure (RF).
  • Age and body surface area were higher in patients with normal kidney function and GHF.

Conclusions:

  • Glomerular hyperfiltration and renal insufficiency are crucial early indicators of kidney damage in sickle cell disease.
  • This study provides the first analysis of kidney function stages in Indian SCD patients.
  • Accurate GFR estimation and monitoring are vital for managing SCD-related nephropathy.

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