A sialosyl sulfonate as a potent inhibitor of influenza virus replication
Ádám Hadházi1, Mauro Pascolutti, Benjamin Bailly
1Institute for Glycomics, Griffith University - Gold Coast Campus, Queensland 4222, Australia. m.vonitzstein@griffith.edu.au.
Abstract:
A new direction for influenza virus sialidase inhibitor development was identified using a sulfonate congener of 2-deoxy-2-β-H N-acetylneuraminic acid. Sialosyl sulfonates can be synthesised efficiently in four steps from N-acetylneuraminic acid via a microwave assisted decarboxylation. The presence of the sulfonate group significantly increases inhibition of influenza virus sialidase and viral infection when compared to the carboxylate congener, and also to the benchmark sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid, Neu5Ac2en.
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