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Measuring functional connectivity in stroke: Approaches and considerations.

Joshua S Siegel1, Gordon L Shulman1, Maurizio Corbetta1,2,3,4,5

  • 11 Department of Neurology, Washington University School of Medicine, St. Louis, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|May 26, 2017
PubMed
Summary

Resting functional magnetic resonance imaging (R-fMRI) is crucial for understanding brain network changes after stroke. This study offers strategies to address confounds in R-fMRI research for cerebrovascular disease, improving data reliability.

Keywords:
Functional MRIMRIbrain ischemiahemodynamicsstroke

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Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Research

Background:

  • Stroke significantly alters brain network functional organization.
  • Resting functional magnetic resonance imaging (R-fMRI) is a valuable non-invasive tool for assessing these changes.
  • Specific challenges exist when applying R-fMRI to stroke patients.

Purpose of the Study:

  • To outline strategies for identifying and mitigating confounds in R-fMRI studies of cerebrovascular disease.
  • To enhance the interpretability and reproducibility of functional connectivity (FC) research in stroke.
  • To provide guidelines for R-fMRI research in conditions affecting brain anatomy or cerebrovascular dynamics.

Main Methods:

  • Discussing strategies for co-registration of lesioned brains.
  • Detailing methods for identifying and removing hemodynamic lags in resting BOLD signals.
  • Addressing the selection of appropriate control cohorts and data acquisition parameters for FC analysis.

Main Results:

  • Identified key confounds in R-fMRI studies of stroke.
  • Provided actionable guidelines for mitigating these confounds.
  • Included a table summarizing confounds and their mitigation approaches.

Conclusions:

  • Implementing these strategies can improve the quality of R-fMRI data in stroke research.
  • Recommendations are applicable to studies of various diseases impacting brain structure or vascular function.
  • Ensuring methodological rigor is essential for reliable FC-stroke findings.