Nutrient-enriched Infant Formula Is Associated With Higher Weight Gain for Low Birth Weight Infants
Michelle Ngan1, Ramon Durazo-Arvizu, Marc G Weiss
1*Department of Public Health Sciences†Department of Pediatrics‡Department of Medicine, Division of Nephrology and Hypertension, Loyola University Chicago, Maywood, IL.
Insights
Nutrient-enriched formulas significantly improved weight gain in low birth weight infants. This study highlights the benefits of specialized nutrition for infant growth and development.
Area of Science:
- Pediatrics
- Neonatology
- Nutritional Science
Background:
- Low birth weight infants require specialized nutrition for optimal growth.
- Nutrient-enriched formulas are designed to provide enhanced nutritional support.
Purpose of the Study:
- To examine the association between nutrient-enriched formula use and weight gain in low birth weight infants.
- To compare weight gain in infants fed enriched versus standard formulas.
Main Methods:
- Retrospective cohort study of 3130 low birth weight infants (1500-2500 g) born in 2010.
- Used data from the Illinois Special Supplemental Nutrition Program for Women, Infants, and Children.
- Multilevel mixed-effects linear regression adjusted for gestational age, birth weight, and breastfeeding history.
Main Results:
- Infants fed enriched formula gained significantly more weight per month in the first 6 months (46.4 g) and 6-12 months (34.0 g) compared to standard formula.
- Findings were consistent across different birth weight subgroups within the low birth weight range.
Conclusions:
- Nutrient-enriched formulas are associated with increased weight gain in low birth weight infants.
- Specialized formulas may play a crucial role in supporting the growth of vulnerable infants.
Objective:
Nutrient-enriched formulas were developed to provide extra nutrients and facilitate optimal growth for low birth weight infants. This study examined the association between use of nutrient-enriched formulas and weight gain among low birth weight infants (birth weight 1500-2500 g).
Methods:
This retrospective cohort study used data from infants enrolled in the Illinois Special Supplemental Nutrition Program for Women, Infants, and Children. Analyses were limited to infants born in 2010 with low birth weight (1500-2500 g, n = 3130). We examined weight gain by use of nutrient-enriched versus standard term formula, which was assigned to the infant by the Women, Infants, and Children program during the first month of life. The analyses used a multilevel mixed-effects linear regression model with random intercepts to determine the association between use of enriched versus standard term formula and weight gain while simultaneously adjusting for confounders including gestational age, birth weight, and history of breast-feeding.
Results:
Among 670 infants in the 1500 to 1999 g birth weight group, those fed enriched formula gained 46.4 g (95% confidence interval 7.4-85.3, P < 0.05) more per month in the first 6 months, and 34.0 g (95% confidence interval -0.4 to 68.3, P = 0.05) more per month >6 to 12 months of age compared with infants using standard term infant formula after adjustment for covariates. Similar findings were noted among the 2460 infants in the 2000 to 2500 g birth weight group.
Conclusions:
Use of nutrient-enriched formulas is associated with higher weight gain in low birth weight infants.
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