Modeling thrombus formation and growth
Related Experiment Video
Updated: Mar 1, 2026

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
Published on: May 24, 2020
Hamid Hosseinzadegan1, Danesh K Tafti1
1Mechanical Engineering Department, Virginia Polytechnic Institute and State University, 213E Goodwin Hall - 0238, 635 Prices Fork Road, Blacksburg, Virginia, 24061.
Abstract:
The paper reviews the state-of-the-art in computational modeling of thrombus formation and growth and related phenomena including platelet margination, activation, adhesion, and embolization. Presently, there is a high degree of empiricism in the modeling of thrombus formation. Based on the experimentally observed physics, the review gives useful strategies for predicting thrombus formation and growth. These include determining blood components involved in atherosclerosis, effective blood viscosity, tissue properties, and methods proposed for boundary conditions. In addition to the guidelines, ongoing research on the effect of shear stress on platelet margination, activation and adhesion, and platelet-surface interactions are reviewed. Biotechnol. Bioeng. 2017;114: 2154-2172. © 2017 Wiley Periodicals, Inc.
More Related Videos
Related Concept Videos
Venous Thrombosis I: Introduction
Clot Retraction and Fibrinolysis

