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Bullous morphoea: a retrospective study.
M Venturi1, A L Pinna2, L Pilloni3
1Section of Dermatology, Mario Aresu Department of Medical Science, University of Cagliari, Cagliari, Italy.
Clinical and Experimental Dermatology
|May 26, 2017
Summary
Bullous morphoea, a rare localized scleroderma variant, was found in 1.4% of cases. This study highlights potential roles for lymphatic vessels and skin trauma in its development.
Area of Science:
- Dermatology
- Pathology
Background:
- Bullous morphoea is a rare variant of localized scleroderma.
- Its pathogenesis remains a subject of discussion.
Observation:
- A retrospective review of 137 morphoea cases (2005-2015) identified 2 bullous morphoea cases.
- This represents 1.4% of morphoea cases, lower than previous reports (7.5%).
Findings:
- Bullous morphoea cases were successfully treated with methotrexate.
- Histopathology revealed basal keratinocyte stretching and altered lymphatic vessels (collapsed or dilated).
Implications:
- Findings suggest a role for lymphatic dysfunction in bullous morphoea development.
- Excessive skin trauma and friction may also contribute to bullous lesion formation.
