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Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
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A Nonmetal-Containing Nitric Oxide Donor Activated with Single-Photon Green Light
Marco Blangetti1, Aurore Fraix2, Loretta Lazzarato1
1Department of Science and Drug Technology, University of Torino, 10125, Torino, Italy.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 26, 2017
Abstract:
Using a facile synthetic route, an organic NO release agent based on a BODIPY light-harvesting antenna was devised. This compound is stable in the dark and delivers NO under photoexcitation with biologically favorable green light. Temporally regulated vasodilation capability is demonstrated on rat aorta by green-light-induced NO release.
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