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Published on: December 5, 2025
Humidified high-flow nasal cannula oxygen in bronchiolitis reduces need for invasive ventilation but not intensive
Chong Tien Goh1, Lynette J Kirby1, David N Schell1
1Paediatric Intensive Care Unit, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Insights
Humidified high-flow nasal cannula oxygen (HHFNC) did not decrease paediatric intensive care unit (PICU) admissions for bronchiolitis. However, HHFNC use outside the PICU reduced the need for invasive ventilation and shortened hospital stays.
Area of Science:
- Pediatric critical care medicine
- Respiratory medicine
- Neonatal and pediatric respiratory care
Background:
- Bronchiolitis is a common pediatric respiratory infection requiring intensive care.
- The use of humidified high-flow nasal cannula (HHFC) oxygen outside the pediatric intensive care unit (PICU) has become widespread.
- Changes in PICU admission patterns and ventilation requirements are anticipated with HHFC use.
Purpose of the Study:
- To evaluate the impact of HHFC oxygen use outside the PICU on admission rates and ventilation requirements for pediatric patients with bronchiolitis.
- To describe changes in PICU admission patterns and ventilation needs following HHFC implementation.
Main Methods:
- Retrospective study design.
- Comparison of bronchiolitis patients admitted to the PICU before and after HHFC implementation (2008, 2011, 2013).
- Analysis of PICU admission rates, intubation rates, and length of stay.
Main Results:
- HHFC use did not reduce PICU admissions.
- Intubation rates decreased significantly from 22.2% in 2008 to 7.8% in 2013.
- Hospital length of stay significantly decreased following HHFC introduction.
- Younger age (<6 months) and RSV bronchiolitis were associated with higher HHFC failure rates.
Conclusions:
- HHFC oxygen used outside the PICU did not reduce PICU admissions or length of stay for bronchiolitis patients.
- HHFC implementation was associated with a decreased need for invasive ventilation.
- HHFC therapy contributed to a reduced overall hospital length of stay.
Aim:
To describe the changes to paediatric intensive care unit (PICU) admission patterns and ventilation requirements for children with bronchiolitis following the introduction of humidified high-flow nasal cannula oxygen outside the PICU.
Methods:
Retrospective study comparing patients <24 months of age with a discharge diagnosis of bronchiolitis admitted to the PICU. A comparison was made between those before humidified high-flow nasal cannula oxygen use (year 2008) to those immediately following the introduction of humidified high-flow nasal cannula oxygen use (year 2011) and those following further consolidation of humidified high-flow nasal cannula oxygen use outside the PICU (year 2013).
Results:
Humidified high-flow nasal cannula oxygen use up to 1 L/kg/min in the hospital did not reduce PICU admission. Intubation rates were reduced from 22.2% in 2008 to 7.8% in 2013. There was a non-significant trend towards decreased length of stay in the PICU while hospital length of stay showed a significant decrease following the introduction of humidified high-flow nasal cannula oxygen. Age <6 months and respiratory syncytial virus bronchiolitis were associated with an increased chance of failing humidified high-flow nasal cannula oxygen therapy.
Conclusion:
Humidified high-flow nasal cannula oxygen utilised outside of the PICU in our institution for children with bronchiolitis did not reduce admission rates or length of stay to the PICU but was associated with a decreasing need for invasive ventilation and reduced hospital length of stay.
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