Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

7.8K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
7.8K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

678
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
678

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EXPRESS: Kinetic modeling of the Tropomyosin Receptor Kinases radioligand [<sup>18</sup>F]TRACK in human brain with high-resolution positron emission tomography.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Gamma auditory steady-state response and remission in antipsychotic-naïve patients at clinical high risk for psychosis: a longitudinal study.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry·2026
Same author

PET imaging of FAAH in chronic Cannabis users: longitudinal assessment during short-term abstinence.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Stress and synaptic density in psychosis and clinical high risk: evidence from [<sup>18</sup>F]SynVesT-1 PET.

Translational psychiatry·2026
Same author

Local chemoarchitecture explains widespread lower cortical thickness associated with clinical high risk for psychosis.

Molecular psychiatry·2026
Same author

Correction: Histamine H3 Receptor as a target for alcohol use disorder: challenging the predictability of animal models for clinical translation in drug development.

Translational psychiatry·2026
Same journal

Analysis of strength degradation of coal and rock masses and stability of mined areas under long term immersion environment.

PloS one·2026
Same journal

Biogenic Silver-Selenium nanocomposite with anticancer activity and potent efficacy against vancomycin-resistant Staphylococcus aureus.

PloS one·2026
Same journal

Preparation and physicochemical characterization of a biodegradable chitosan/carboxymethyl cellulose hydrogel synthesized in NaOH/urea medium.

PloS one·2026
Same journal

Action-guilt, survivor-guilt, and depression in combat-related PTSD.

PloS one·2026
Same journal

Explainable machine learning for predicting activities of daily living at discharge in stroke patients: A retrospective study using SHAP interpretability.

PloS one·2026
Same journal

Deep learning based two-way feature depiction model for brain tumor detection.

PloS one·2026
See all related articles

Related Experiment Video

Updated: Mar 1, 2026

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

11.0K

Feasibility study of TSPO quantification with [18F]FEPPA using population-based input function.

Rostom Mabrouk1, Antonio P Strafella1,2,3,4, Dunja Knezevic1

  • 1Research Imaging Centre, Centre for Addiction and Mental Health (CAMH), Toronto, Ontario, Canada.

Plos One
|May 26, 2017
PubMed
Summary
This summary is machine-generated.

A single blood sample can individualize the input function (IF) for Translocator protein 18 kDa positron emission tomography (PET) imaging. This method estimates total distribution volume (VT) but may require larger sample sizes for equivalent statistical power.

More Related Videos

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.9K
Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
09:58

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Published on: November 9, 2018

8.1K

Related Experiment Videos

Last Updated: Mar 1, 2026

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
09:03

Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET

Published on: October 22, 2019

11.0K
Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function
10:21

Continuous Blood Sampling in Small Animal Positron Emission Tomography/Computed Tomography Enables the Measurement of the Arterial Input Function

Published on: August 8, 2019

8.9K
Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury
09:58

Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury

Published on: November 9, 2018

8.1K

Area of Science:

  • Nuclear medicine and molecular imaging.
  • Radiopharmaceutical quantification.
  • Neuroscience and neurodegenerative disease research.

Background:

  • Quantifying Translocator protein 18 kDa (TSPO) with positron emission tomography (PET) relies on the input function (IF).
  • A suitable reference region with negligible binding has not been identified, necessitating arterial blood sampling for the IF (ASIF).
  • Individualizing the population-based input function (PBIF) using a single arterial sample offers a potential alternative to ASIF.

Purpose of the Study:

  • To individualize a population-based input function (PBIF) using a single arterial blood sample for estimating total distribution volume (VT) of [18F]FEPPA.
  • To replicate previously published clinical studies that utilized the arterial blood sampling input function (ASIF).

Main Methods:

  • Reanalyzed data from 3 prior [18F]FEPPA studies including healthy controls (HC), Parkinson's disease (PD), and Alzheimer's disease (AD) patients.
  • Employed PBIF with Logan graphical analysis (GA), neglecting vascular contribution, to estimate VT.
  • Determined optimal PBIF calibration based on IF area under the curve (AUC) and VT agreement between methods, considering rs6971 polymorphism.

Main Results:

  • PBIF scaled with a single activity value (average of 60- and 90-min samples) showed good agreement with ASIF and optimized IF AUC.
  • Gray matter VTs estimated by PBIF strongly correlated with ASIF in HC (r2 = 0.82).
  • PBIF slightly underestimated VT compared to ASIF, and ASIF AUC was independent of genotype and disease state.

Conclusions:

  • A single arterial blood sample at 75 minutes post-injection is sufficient to individualize the IF for the studied subject groups.
  • The increased variability associated with PBIF necessitates a larger sample size to achieve the same statistical power as ASIF.