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The Perinatal Asphyxiated Lamb Model: A Model for Newborn Resuscitation

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Systemic necrotizing polyarteritis in three weaned lambs from one flock.

Mark Wessels^1,2,3,4, Ben Strugnell^1,2,3,4, Nick Woodger^1,2,3,4

¹Finn Pathologists, Weybread, Diss, Norfolk, UK (Wessels, Woodger).

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

|May 27, 2017

Summary

Systemic necrotizing polyarteritis affected three lambs, causing fatal hemorrhage and vasculitis. An immune-mediated process may link the vasculitis and enteritis, as no infectious cause was found.

Keywords:

Systemic necrotizing polyarteritis T-lymphocyte–associated enteritis sheep

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Area of Science:

Veterinary Pathology
Immunology

Background:

Systemic necrotizing polyarteritis is a rare vasculitis affecting multiple organs.
Necrotizing vasculitis in lambs can lead to severe gastrointestinal and systemic complications.

Observation:

Three lambs presented with necrotizing vasculitis, hemorrhage, and lymphocytic enteritis.
Affected organs included the small intestine, abomasum, mesentery, kidney, and heart.
Immunohistochemistry revealed T-cell and macrophage infiltrates in vascular lesions.

Findings:

No viral etiology (pestivirus) was identified through PCR or viral microarray.
A common genetic cause was unlikely due to unrelated lambs.
Concurrent T-lymphocyte-associated enteritis suggests a potential immune-mediated mechanism.

Implications:

The findings suggest a possible immune-mediated etiology for systemic necrotizing polyarteritis in lambs.
Further research is needed to elucidate the specific triggers and pathogenesis.
Understanding the immune basis may inform future diagnostic and therapeutic strategies for similar conditions.