Related Experiment Video
Updated: Mar 1, 2026
09:27
Rapid One-step Enzymatic Synthesis and All-aqueous Purification of Trehalose Analogues
Published on: February 17, 2017
10.8K
Current pharmacological developments in 2,3,4',5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG)
Jingjing Wu1, Wenfeng Hu2, Yu Gong2
1Department of Cardiology, Suzhou Kowloon Hospital of Shanghai Jiaotong University School of Medicine, #118 Wansheng Street, Suzhou 215021, Jiangsu, China.
European Journal of Pharmacology
|May 27, 2017
Summary
2,3,4
Area of Science:
- Pharmacology and Traditional Chinese Medicine
Background:
- 2,3,4',5-tetrahydroxystilbene 2-O-β-D-glucoside (TSG) is a resveratrol analog from Polygonum multiflorum.
- TSG exhibits potent anti-inflammatory, anti-oxidative, anti-apoptotic, and free radical scavenging properties.
- Its therapeutic potential is recognized for various diseases, including neurodegeneration and atherosclerosis.
Purpose of the Study:
- To summarize current pharmacological developments of TSG.
- To elucidate the mechanisms behind TSG's protective effects.
- To explore novel applications and preclinical assessments of TSG.
Main Methods:
- Literature review of existing studies on TSG.
- Analysis of in vitro and in vivo experimental data.
- Synthesis of information on TSG's pharmacological activities and mechanisms.
Main Results:
- TSG demonstrates protective effects against neuronal, cardiomyocyte, and endothelial cell injury.
- It prevents pro-inflammatory cytokine production and ameliorates inflammatory responses in various models.
- TSG also shows benefits in vascular smooth cell proliferation, gastrointestinal dysfunction, platelet aggregation, and cognitive function.
Conclusions:
- TSG possesses broad pharmacological activities beneficial for disease prevention and therapy.
- Further research is needed to fully understand its mechanisms and preclinical applications.
- TSG holds promise as a therapeutic agent for aging and Alzheimer's disease.
Keywords:
2,3,4′,5-tetrahydroxystilbene 2-O-β-D-glucosideApoptosisDiseaseInflammationOxidative stressMore Related Videos
Related Concept Videos
01:24Phase II Reactions: Glucuronidation
1.9K
Glucuronidation, a pivotal phase II biotransformation process, involves the coupling of glucuronic acid to a drug or xenobiotic. Given its widespread occurrence and critical role in drug metabolism, it's considered the most crucial phase II reaction. It enhances the water solubility of substances, aiding their expulsion from the body. The driving force behind these reactions is a group of enzymes known as UDP-glucuronosyltransferases (UGTs). UGTs facilitate the transfer of a glucuronic acid...
1.9K
01:14Drug Metabolism: Phase II Reactions
5.4K
Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...
5.4K
01:11Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
56
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
56
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
284
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
284
01:27Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase
42
Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...
42
01:18Transdermal Drug Delivery Systems
60
Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
60