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Atypical presentations of MERS-CoV infection in immunocompromised hosts

Si-Ho Kim1, Jae-Hoon Ko1, Ga Eun Park1

  • 1Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 135-710, Republic of Korea.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|May 27, 2017
PubMed

Insights

Atypical Middle East Respiratory Syndrome Coronavirus (MERS-CoV) presentations occurred in immunocompromised patients during the 2015 Korean outbreak. Recognizing these MERS-CoV variations is crucial for patient management and outbreak control.

Area of Science:

  • Infectious Diseases
  • Virology
  • Immunocompromised Host Research

Background:

  • The 2015 Korean Middle East Respiratory Syndrome Coronavirus (MERS-CoV) outbreak highlighted the need to understand viral behavior in diverse patient populations.
  • Immunocompromised individuals may present unique challenges in MERS-CoV infection diagnosis and management due to altered immune responses.

Observation:

  • Three immunocompromised patients exhibited atypical MERS-CoV infection patterns during the 2015 outbreak.
  • Case 1: Delayed symptom onset following a four-day asymptomatic incubation period.
  • Case 2: An extended 20-day incubation period observed.
  • Case 3: Persistent MERS-CoV viral shedding without significant clinical decline.

Findings:

  • Atypical MERS-CoV presentations, including extended incubation and delayed symptom development, can occur in immunocompromised hosts.
  • Persistent viral shedding without clinical deterioration was observed in one case, complicating transmission risk assessment.
  • These variations underscore the complexity of MERS-CoV infection dynamics in vulnerable populations.

Implications:

  • Early recognition of these atypical MERS-CoV presentations is vital for effective patient isolation and treatment strategies.
  • Understanding these variations is critical for implementing robust public health measures to prevent and control MERS outbreaks.
  • Further research into MERS-CoV pathogenesis in immunocompromised individuals is warranted to refine clinical guidelines.
Keywords:
Asymptomatic periodCorticosteroidImmunocompromised hostIncubation periodMiddle East respiratory syndrome coronavirus

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