The mechanism of ischemia-induced brain cell injury. The membrane theory
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1Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
Neurochemical Pathology
|July 1, 1988
Abstract:
Temporal ischemia of the brain injures only the selectively vulnerable brain cells. The dying process evolves along with glutamate-mediated intracellular signal-transduction system, together with a loss of Ca2+ homeostasis. Such post-ischemic changes eventually disrupt functional and structural integrity of the cell membrane and kill the neuron. Molecular basis in pharmacoprotective agents is discussed.