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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Updated: Mar 1, 2026

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Adjunctive Therapies for Bacterial Keratitis.

Turki Abdulaziz Bin Dakhil1, Donald U Stone1,2,3, David C Gritz1,2,3

  • 1Anterior Segment Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Middle East African Journal of Ophthalmology
|May 27, 2017
PubMed
Summary

This systematic review examines adjunctive treatments for bacterial keratitis, a common eye infection. It guides clinical decisions for managing complications beyond standard antibiotic therapy.

Keywords:
Adjunctive therapybacterial keratitiscorneal ulcer

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Area of Science:

  • Ophthalmology
  • Microbiology
  • Infectious Diseases

Background:

  • Bacterial keratitis is the leading cause of infectious keratitis worldwide.
  • Current standard treatment relies heavily on antibiotics.
  • Complications such as corneal thinning, perforation, and poor wound healing necessitate further therapeutic strategies.

Purpose of the Study:

  • To systematically review clinical studies on adjunctive treatments for bacterial keratitis.
  • To provide evidence-based guidance for clinical decision-making in managing this condition.
  • To explore various therapeutic options beyond primary antibiotic treatment.

Main Methods:

  • Systematic review of published clinical studies.
  • Inclusion of animal and laboratory studies, case reports, case series, and randomized clinical trials.
  • Analysis of adjunctive medications and surgical interventions for bacterial keratitis.

Main Results:

  • Identified various adjunctive therapies for bacterial keratitis.
  • Evaluated the efficacy of different treatments in managing complications.
  • Synthesized findings from diverse study designs to inform clinical practice.

Conclusions:

  • Adjunctive treatments play a crucial role in managing bacterial keratitis and its complications.
  • Evidence supports the use of specific medications and surgical approaches.
  • Further research may refine optimal adjunctive strategies for improved patient outcomes.