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Reprogramming the oncogenic response: SET protein as a potential therapeutic target in cancer

Man-Hsin Hung1,2, Kuen-Feng Chen3

  • 1a Division of Medical Oncology, Department of Oncology , Taipei Veterans General Hospital , Taipei , Taiwan.

Expert Opinion on Therapeutic Targets
|May 27, 2017
PubMed
Abstract

Insights

The SET protein drives cancer initiation, progression, and therapeutic resistance. Targeting SET and its interactions offers a promising anti-cancer strategy, though further research is needed for optimal clinical application.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The SET protein is an oncoprotein implicated in cancer initiation and progression.
  • SET overexpression is tumor-specific and linked to poor clinical outcomes across various malignancies.
  • SET contributes to the development of therapeutic resistance in cancer cells.

Purpose of the Study:

  • To review the oncogenic roles, biological functions, and clinical relevance of SET protein in cancer.
  • To discuss the anti-cancer effects of preclinical SET antagonists.

Main Methods:

  • Literature review of existing evidence on SET protein in cancer.
  • Summary of preclinical investigations into SET antagonists.

Main Results:

  • SET plays a critical role in regulating diverse cancer hallmarks.
  • Emerging evidence highlights SET's involvement in therapeutic resistance.
  • Three SET antagonists show potential anti-cancer effects in preclinical studies.

Conclusions:

  • Targeting SET-associated protein interfaces is a potential anti-cancer strategy.
  • Further research is required to optimize combination therapies involving SET antagonists.
  • Identifying biomarkers for predicting responsiveness to SET-targeted treatments is crucial.
Keywords:
PP2ASETcanceroncoproteintarget therapy

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