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Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

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Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
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Single Nucleotide Polymorphisms-SNPs01:05

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
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Application of Laser Microdissection to Uncover Regional Transcriptomics in Human Kidney Tissue
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Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.

Mathias Gorski, Peter J van der Most, Alexander Teumer

    Scientific Reports
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    Summary
    This summary is machine-generated.

    This study corrects a previously published article DOI. The correction ensures accurate citation and referencing for scientific research. This is important for maintaining the integrity of scientific literature.

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    Area of Science:

    • Scientific Publishing
    • Scholarly Communication

    Background:

    • Ensuring accuracy in scientific literature is crucial.
    • Proper citation and referencing maintain research integrity.

    Purpose of the Study:

    • To correct the Digital Object Identifier (DOI) of a published article.
    • To provide accurate metadata for scholarly works.

    Main Methods:

    • Article DOI correction process.
    • Metadata update in scholarly databases.

    Main Results:

    • The article DOI has been successfully corrected.
    • Updated DOI ensures proper identification and access to the research.

    Conclusions:

    • Accurate DOIs are essential for the reproducibility and traceability of scientific findings.
    • This correction upholds the standards of scientific publishing.