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Related Experiment Video

Updated: Mar 1, 2026

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Brain Death Induction in Mice Using Intra-Arterial Blood Pressure Monitoring and Ventilation via Tracheostomy

Published on: April 17, 2020

Current controversies in brain death determination.

Ariane Lewis¹, David Greer²

¹NYU Langone Medical Center, Departments of Neurology and Neurosurgery, Division of Neurocritical Care, 530 First Avenue HCC-5A, New York, New York 10016, USA.

Nature Reviews. Neurology

|May 27, 2017

Summary

This summary is machine-generated.

Controversies persist regarding brain death determination despite widespread acceptance. This article examines cases and advocates for standardized American Academy of Neurology (AAN) criteria to ensure consistent medical practice.

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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

Published on: June 3, 2020

Area of Science:

Neurology
Medical Ethics
Legal Medicine

Background:

The concept of brain death is widely accepted but determination protocols face persistent controversy.
Public attention is often drawn to complex brain death cases.
Variability in diagnostic protocols and objections to organ support cessation fuel ongoing debate.

Purpose of the Study:

To analyze prominent controversial brain death cases from 2013-2016.
To review current controversies surrounding brain death determination.
To advocate for the standardization and endorsement of established criteria.

Main Methods:

Examination of four high-profile controversial brain death cases.
Review of existing literature and guidelines on brain death determination.
Analysis of legal and ethical objections to organ support discontinuation.

Main Results:

Identified key areas of controversy including protocol variability and management of objections.
Highlighted the need for consistent application of diagnostic criteria.
Demonstrated the persistence of legal and ethical challenges in brain death cases.

Conclusions:

Brain death is conceptually and legally valid.
Standardization of the American Academy of Neurology (AAN) criteria is crucial to reduce protocol variability.
Medical societies and regulatory bodies must fully endorse AAN criteria as accepted medical standards.