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Inhibition of human lymphocyte cyclic nucleotide phosphodiesterases by the chlorinated adenosine analog DTA-35
M Y Hurwitz1, R L Hurwitz, R D Edstrom
1Department of Biochemistry, University of Minnesota, Minneapolis 55455.
Journal of Enzyme Inhibition
|January 1, 1987
Abstract:
Human (E+)-T-lymphocytes have multiple cyclic nucleotide phosphodiesterase activities, some of which are markedly inhibited by the chlorinated adenosine derivative 9-(3',5'-dichloro-2',3',5'-trideoxy-beta-D-threo-pentofuranosyl)adenine (DTA-35).