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Secondary-Rim γ-Cyclodextrin Functionalization to Conjugate with C60 : Improved Efficacy as a Photosensitizer
Xiaolei Zhu1, Annamaria Quaranta2, René V Bensasson3
1Sorbonne Universités, UPMC Univ Paris 06, CNRS, Insititut Parisien de Chimie Moléculaire (UMR 8232), 4 Place Jussieu, 75005, Paris, France.
Abstract:
DIBAL-H-mediated demethylation provides a novel method to access secondary-rim functionalized γ-cyclodextrin. 2A ,3B -Dihydroxyl-per-O-methylated-γ-cyclodextrin has been obtained, whose conjugation with C60 allows access to the most water-soluble C60 conjugate described so far. The water solubility of 0.12 m (550 mg mL-1 ) is 150 times higher than that of the native γ-CD/C60 complex. Its singlet oxygen (1 O2 ) quantum yield is 0.39, an increase of one to two orders of magnitude compared to that of α(β)CD-C60 conjugates.
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