[Changes in synaptic potentials and axonal delays as factors causing epileptic instability of neuronal networks]

Synaptic weights, axonal delays and excitability thresholds are three basic parameters influencing the function of neuronal network as a dynamic system. Changes of the general level of the signal flow, without changes in relation between excitatory and inhibitory connections can cause pathologic oscillations in the network. The conductivity in neuronal nets depends on electrochemical processes and may be influenced by the pH-status, ion concentrations, among other parameters. Also different pathological processes can change it. Even slight changes of axonal delays, as shown above, can cause in certain situations unstable, epileptic oscillations of the net.