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Related Experiment Video

Updated: Mar 1, 2026

Enrichment of Native Lipoprotein Particles with microRNA and Subsequent Determination of Their Absolute/Relative microRNA Content and Their Cellular Transfer Rate
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Remnant lipoproteins.

Anette Varbo1, Børge G Nordestgaard

  • 1aDepartment of Clinical Biochemistry bThe Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital cFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Current Opinion in Lipidology
|May 27, 2017
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Summary

Remnant cholesterol, linked to cardiovascular disease risk, can be reduced by medications. Large-scale studies are ongoing to confirm its role in reducing residual cardiovascular risk, especially in obese and diabetic populations.

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Area of Science:

  • Cardiovascular Medicine
  • Lipid Metabolism
  • Atherosclerosis Research

Background:

  • Remnant lipoproteins (RLPs) are implicated in atherosclerosis development.
  • Elevated remnant cholesterol contributes to residual cardiovascular disease (CVD) risk, particularly in individuals with obesity and diabetes.
  • Understanding RLPs is crucial for managing CVD, a leading global health concern.

Purpose of the Study:

  • To review recent advancements in remnant lipoproteins and remnant cholesterol.
  • To focus on the association between remnant cholesterol and cardiovascular disease risk.
  • To synthesize current knowledge on therapeutic strategies targeting remnant cholesterol.

Main Methods:

  • Review of recent observational studies.
  • Analysis of genetic studies on remnant lipoproteins.
  • Examination of mechanistic studies investigating RLP involvement in atherosclerosis.
  • Assessment of data from smaller-scale studies and post hoc analyses on drug efficacy.

Main Results:

  • Consistent evidence from observational, genetic, and mechanistic studies confirms RLPs' role in atherosclerosis and CVD risk.
  • High remnant cholesterol levels may explain residual CVD risk post-low-density lipoprotein (LDL) cholesterol reduction.
  • Obesity and diabetes, increasing global health issues, are associated with elevated remnant cholesterol concentrations.

Conclusions:

  • Remnant cholesterol is a significant risk factor for cardiovascular disease.
  • Various drug classes have demonstrated the ability to lower remnant cholesterol.
  • Large-scale clinical trials investigating CVD risk reduction via RLP lowering are currently underway.