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Does Modic Change Progresss With Age?

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Modic changes (MC) prevalence increases with age, peaking in the 60s, but declines thereafter, suggesting it may not simply progress with aging. This study analyzed MC trends in elderly patients using MRI.

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Area of Science:

  • Radiology
  • Orthopedics
  • Geriatrics

Background:

  • Modic change (MC) is discussed for its clinical significance, but research often excludes elderly patients.
  • Previous studies suggest MC prevalence increases with age, but data in older populations is limited.

Purpose of the Study:

  • To investigate the prevalence and age-related trends of Modic change (MC) in an elderly patient cohort.
  • To clarify if Modic change (MC) prevalence consistently increases with advancing age.

Main Methods:

  • A cross-sectional study analyzed lumbar MRI scans of 585 patients (mean age 65) recruited between 2013 and 2015.
  • Modic change (MC) was identified and classified into types (MT1, MT2, MT3, mixed) using T1- and T2-weighted MRI.
  • Prevalence trends of MC were analyzed across different age groups.

Main Results:

  • Modic change (MC) was identified in 36.0% of patients.
  • Prevalence increased with age, reaching 44% in the 60s and 42% in the 70s, then decreasing to 26% in the 80s.
  • Modic type 2 (MT2) was the most common type (81.3%).

Conclusions:

  • Modic change (MC) prevalence shows an age-related increase but plateaus and declines after the 60s.
  • These findings indicate that MC may not be a simple progressive condition throughout life, especially after age 70.
  • Further research is needed to understand the complex relationship between aging and Modic change (MC).