En-face time-domain optical coherence tomography with dynamic focus for high-resolution imaging
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Updated: Mar 1, 2026

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
Published on: October 2, 2021
Mohammad R N Avanaki1, Adrian Podoleanu2
1Wayne State University, Department of Biomedical Engineering, Detroit, Michigan, United StatesbWayne State University, School of Medicine, Department of Dermatology, Detroit, Michigan, United StatescBarbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States.
Abstract:
Optical coherence tomography (OCT) is capable of imaging microstructures within translucid samples. A time-domain version of the OCT technology is employed here due to its compatibility with the dynamic focus (DF) procedure. DF means moving the confocal gate in synchronism with the depth scanning via the coherence gate. A DF-OCT setup was implemented for imaging samples at 1300 nm. Its confocal gate of 180 ?? ? m allows the achievement of good and similar transversal resolution along its much larger axial range. Images of a phantom, human skin, teeth, and larynx with and without DF are demonstrated.
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