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Updated: Mar 1, 2026

In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells
Published on: January 20, 2019
Plasticity of immune system vs. memory therapy IST
A Tammaro1, I Romano1, F Persechino2
1Dermatology Unit*, NESMOS Department, S. Andrea Hospital, University of Rome "Sapienza", Rome, Italy.
Background:
Pharmacotherapy and immunotherapy are the main treatments for allergic diseases to inhalants.
Objective:
This study investigates whether to repeat short cycles of immunotherapy after 3 or 5 years the from interruption of the first therapeutic cycle, lasting 3-4 years, to maintain immune memory in individuals subjected to IST.
Methods And Results:
We have compared two groups, one of 452 patients who, after the first treatment for 3-4 years of IST, performed a cycle of four months after three and 10 years from the suspension, and a second group of 126 individuals who have performed only the IST treatment for 3-4 years. The best results were obtained in the first group.
Conclusions:
These results are due to the immune system's plasticity, a very important concept in clinical practice.
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