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Related Experiment Video

Updated: Mar 1, 2026

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
06:25

Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole

Published on: December 5, 2025

372

Microneedles in the clinic.

Shubhmita Bhatnagar1, Kaushalkumar Dave2, Venkata Vamsi Krishna Venuganti1

  • 1Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, India.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 28, 2017
PubMed
Summary

Microneedle technology, reducing needle size to the micron scale, shows significant promise in cosmetic and therapeutic applications. This review details clinical studies on microneedles for skin conditions, vaccinations, and diabetes management.

Keywords:
Collagen inductionFractional radiofrequencyMicroneedlesSkin rejuvenationTranscutaneous immunizationTransdermal drug delivery

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Area of Science:

  • Biomedical Engineering
  • Dermatology
  • Pharmacology

Background:

  • Reducing physical dimensions of devices profoundly impacts their properties and performance.
  • Microneedle technology has gained significant research interest for its diverse applications.
  • Numerous microneedle-based products have been approved, with ongoing clinical trials investigating their efficacy and safety.

Purpose of the Study:

  • To provide a comprehensive overview of clinical studies involving microneedle-based technologies.
  • To detail approved and investigational microneedle devices for cosmetic, therapeutic, and diagnostic uses.
  • To summarize clinical outcomes of microneedle applications.

Main Methods:

  • Review of completed and ongoing clinical studies.
  • Analysis of microneedle designs and applications in clinical investigations.
  • Compilation of clinical reports for various applications.

Main Results:

  • Microneedles are extensively studied for cosmetic uses like acne vulgaris, acne scars, skin rejuvenation, and hair growth.
  • Clinical applications for therapeutic purposes include influenza and polio vaccinations, and diabetes management.
  • Several microneedle-based products have gained regulatory approval and are commercially available.

Conclusions:

  • Microneedle technology has demonstrated significant clinical progress and potential across cosmetic and therapeutic fields.
  • Ongoing clinical trials continue to explore the safety and efficacy of microneedle systems.
  • This review offers a first-time comprehensive summary of clinical efforts and outcomes in microneedle-based systems.