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Updated: Mar 1, 2026

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Telomere Length and Telomerase Activity; A Yin and Yang of Cell Senescence

Published on: May 22, 2013

Cardiac telomere length in heart development, function, and disease.

S A Booth¹, F J Charchar^2,3,4

¹Faculty of Science and Technology, School of Applied and Biomedical Sciences, Federation University Australia, Balllarat, Australia.

Physiological Genomics

|May 28, 2017

Summary

This summary is machine-generated.

Telomere length (TL) in heart cells is crucial for cardiac function and regeneration. Maintaining cardiac TL through lifestyle changes may prevent heart disease and aid recovery.

Keywords:

apoptosis cardiac hypertrophy cardiomyocytes heart disease senescence telomere length

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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer

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Published on: April 13, 2015

Area of Science:

Cardiology
Molecular Biology
Genetics

Background:

Telomeres protect chromosome ends; their shortening (reduced telomere length, TL) triggers cellular aging and death.
Heart disease, a leading cause of mortality, involves cardiac cell loss potentially linked to decreased TL.
Cardiac TL exhibits cell-specific regulation and dynamic changes during development and disease progression.

Purpose of the Study:

To critically review the relationship between cardiac telomere length and heart function.
To explore factors influencing cardiac TL and their impact on heart health.
To assess the potential of TL as a biomarker for cardiac rejuvenation.

Main Methods:

Review of studies measuring telomeres specifically in heart cells.
Analysis of factors affecting cardiac TL, including oxidative stress, hypoxia, and interventions.
Evaluation of evidence linking cardiac TL to heart disease onset, progression, and development.

Main Results:

Cardiac TL changes rapidly during heart development and disease.
Factors like oxidative stress and hypoxia decrease cardiac TL and heart function.
Antioxidants, calorie restriction, and exercise show potential in preserving cardiac TL and function.

Conclusions:

Cardiac TL is involved in heart function, development, and disease.
Further research is needed to address limitations in animal models and confounding factors.
Understanding telomeric mechanisms in the heart offers promise for preventing dysfunction and enhancing regeneration.