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Related Concept Videos

Sleep Apnea01:21

Sleep Apnea

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Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
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Sleep-Wake Cycles01:24

Sleep-Wake Cycles

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Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
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Heart Failure VI: Adjunct Therapies01:22

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Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
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Other Pulmonary Disorders01:17

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Amyloid Fibrils03:03

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Amyloid Burden in Obstructive Sleep Apnea.

Chang-Ho Yun1, Ho-Young Lee2, Seung Ku Lee3

  • 1Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Journal of Alzheimer'S Disease : JAD
|May 28, 2017
PubMed
Summary
This summary is machine-generated.

Obstructive sleep apnea (OSA) is linked to increased amyloid deposition in the brain, a key marker for Alzheimer's disease. This finding suggests OSA may accelerate Alzheimer's development.

Keywords:
Alzheimer’s diseasecerebral cortexdementiapositron-emission tomographysleep

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Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Gerontology

Background:

  • Obstructive sleep apnea (OSA) is a prevalent condition associated with various health issues.
  • Amyloid deposition in the brain is a hallmark of Alzheimer's disease (AD).
  • A potential biological link between OSA and AD through amyloid accumulation is hypothesized.

Purpose of the Study:

  • To investigate whether OSA increases cerebral amyloid burden compared to controls.
  • To examine the relationship between OSA and amyloid deposition using Positron Emission Tomography (PET) imaging.

Main Methods:

  • Adult participants (50-65 years) from the Korean Genome and Epidemiology Study were included.
  • Nineteen OSA patients (Apnea-Hypopnea Index [AHI] ≥15/h) and 19 matched controls (AHI 1.8/h) underwent polysomnography, MRI, and 11C-PiB PET scans.
  • Voxel-wise analysis of PiB-PET images compared amyloid deposition between groups, controlling for covariates like hypertension and diabetes.

Main Results:

  • The OSA group exhibited significantly higher PiB deposition in the right posterior cingulate gyrus and right temporal cortex compared to controls (corrected p < 0.05).
  • No brain regions showed higher PiB uptake in controls relative to OSA patients.
  • No significant regional differences in cortical thickness were observed between the groups.

Conclusions:

  • Obstructive sleep apnea is associated with increased cerebral amyloid deposition.
  • OSA may accelerate amyloid accumulation, potentially contributing to the development or progression of Alzheimer's disease.