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Effect of renal function status on the prognostic value of heart rate in acute ischemic stroke patients

Zhengbao Zhu1, Chongke Zhong2, Tian Xu3

  • 1Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, Jiangsu, China.

Atherosclerosis
|May 28, 2017
PubMed

Insights

High heart rate predicts poor outcomes in acute ischemic stroke patients with abnormal renal function. Heart rate reduction may improve prognosis in this vulnerable group.

Area of Science:

  • Cardiology
  • Neurology
  • Nephrology

Background:

  • The prognostic significance of heart rate in ischemic stroke is debated.
  • The influence of renal function on this association is not well understood.

Purpose of the Study:

  • To investigate the relationship between heart rate and prognosis in acute ischemic stroke.
  • To determine if renal function modifies this association.

Main Methods:

  • Prospective multicenter study of 3923 ischemic stroke patients from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS).
  • Primary outcome: composite of death and major disability at 3 months.
  • Secondary outcomes: death and major disability separately.

Main Results:

  • Renal function status significantly modified the association between heart rate and stroke prognosis (pinteraction = 0.037).
  • High heart rate was linked to increased risk of poor prognosis in patients with abnormal renal function (OR, 1.61).
  • A linear association was observed between heart rate and risk of poor prognosis in patients with abnormal renal function (p for linearity = 0.002).

Conclusions:

  • Elevated heart rate is a strong predictor of poor prognosis in acute ischemic stroke patients with impaired renal function.
  • Heart rate reduction interventions may be beneficial for improving outcomes in these patients.
Abstract

Keywords:
Heart rateIschemic strokePrognosisRenal function

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