Related Experiment Video

Updated: Mar 1, 2026

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment
08:36

Author Spotlight: Evaluating the Adjuvant Efficacy and Safety of Angong Niuhuang Pill in Viral Encephalitis Treatment

Published on: April 19, 2024

1.3K

Antibiotics and mania: A systematic review

Simon Lambrichts1, Lukas Van Oudenhove2, Pascal Sienaert3

  • 1KU Leuven, University Psychiatric Center KU Leuven, Herestraat 49, 3000 Leuven / Leuvensesteenweg 517, 3070 Kortenberg, Belgium.

Journal of Affective Disorders
|May 28, 2017
PubMed
Abstract

Insights

Antibiotic-induced mania, or antibiomania, is a rare phenomenon. While 47 cases are reported, the exact mechanism remains unknown, necessitating drug discontinuation if suspected.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Neurology

Background:

  • Mania can manifest secondary to medical conditions or pharmacological treatments.
  • Antibiotic-induced mania (antibiomania) is considered a rare adverse effect.
  • This phenomenon can occur in individuals with or without a prior history of affective disorders.

Purpose of the Study:

  • To review and compile published reports of antibiomania.
  • To explore potential mechanisms underlying antibiotic-induced mania.
  • To provide insights into the management of this condition.

Main Methods:

  • A comprehensive MEDLINE search was conducted.
  • Manual cross-referencing was employed to identify relevant literature.
  • Cases were included if a (hypo)manic episode occurred in close temporal proximity to antibiotic prescription.

Main Results:

  • A total of 47 cases of antibiomania were identified in the literature.
  • Patient ages ranged from 3 to 77 years, with a mean age of 40.
  • Antitubercular agents, macrolides, and quinolones were the most frequently implicated antibiotic classes.

Conclusions:

  • Antibiotic use can be associated with the development of (hypo)manic episodes.
  • The low number of reported cases limits the ability to determine incidence or issue specific warnings.
  • Discontinuation of the suspected antibiotic and standard treatment for manic symptoms are recommended; the underlying mechanism is still unclear.
Keywords:
AntibiomaniaAntibioticsBipolar disorderReview

More Related Videos

Developing a Rat Model for Bipolar Disorder04:42

Developing a Rat Model for Bipolar Disorder

Published on: May 2, 2025

1.5K
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

13.5K

Related Concept Videos

Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
708
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
1.1K
Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
1.2K
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.1K
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
333
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
642