Related Experiment Video
Updated: Mar 1, 2026
Surgical Models of Gastroesophageal Reflux with Mice
Published on: August 25, 2015
Gastroesophageal reflux
Bethany J Slater1, Steven S Rothenberg1
1Pediatric Surgery, Rocky Mountain Hospital for Children, Denver, Colorado.
Insights
Gastroesophageal reflux disease (GERD) in children often requires surgery when medical treatments fail. Laparoscopic Nissen fundoplication is the standard surgical approach for pediatric GERD, focusing on specific technical steps for optimal outcomes.
Area of Science:
- Pediatric Surgery
- Gastroenterology
Background:
- Gastroesophageal reflux disease (GERD) affects 7-20% of children, presenting with symptoms like regurgitation, feeding irritability, and respiratory issues.
- Medical management, including dietary changes and medications, is the initial treatment approach for pediatric GERD.
Purpose of the Study:
- To outline the indications and standard surgical technique for managing pediatric GERD.
- To detail the key technical aspects of laparoscopic Nissen fundoplication in children.
Main Methods:
- Review of indications for surgical intervention in pediatric GERD.
- Description of the standard laparoscopic Nissen fundoplication procedure for children.
Main Results:
- Surgical intervention is indicated for pediatric GERD when medical therapy fails, leading to poor weight gain, failure to thrive, persistent respiratory symptoms, or complications like esophagitis.
- Laparoscopic Nissen fundoplication is the established surgical standard of care.
Conclusions:
- Laparoscopic Nissen fundoplication is a safe and effective surgical treatment for pediatric GERD unresponsive to medical management.
- Precise technical execution, including adequate intra-abdominal esophagus creation, crural repair, and a floppy 360° wrap, is crucial for successful outcomes.
Abstract:
Gastroesophageal reflux disease (GERD) is a very common condition and affects approximately 7-20% of the pediatric population. Symptoms from pathological GERD include regurgitation, irritability when feeding, respiratory problems, and substernal pain. Treatment typically starts with dietary modifications and postural changes. Antireflux medications may then be added. Indications for operative management in the pediatric population include failure of medical therapy with poor weight gain or failure to thrive, continued respiratory symptoms, and complications such as esophagitis. Laparoscopic Nissen fundoplication has become the standard of care for surgical treatment of children with GERD. The key technical aspects of laparoscopic Nissen fundoplication include creation of an adequate intra-abdominal esophagus, minimal dissection of the hiatus with exposure of the right crus to identify the gastroesophageal junction, crural repair, and creation of floppy, 360° wrap that is oriented at the 11 o׳clock position.
More Related Videos
Related Concept Videos
01:29Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
01:30Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
01:21Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
01:21Barrett Esophagus-I: Introduction
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
01:30Other Disorders of Digestive System