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Updated: Mar 1, 2026
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Conditional Reprogramming of Pediatric Human Esophageal Epithelial Cells for Use in Tissue Engineering and Disease Investigation
Published on: March 22, 2017
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Neonatal and pediatric esophageal perforation
Rebecca M Rentea1, Shawn D St Peter1
1Deparment of Surgery, Children׳s Mercy Hospital, 2401 Gillham Rd, Kansas City, Missouri 64108.
Seminars in Pediatric Surgery
|May 29, 2017
Summary
Esophageal perforation (EP) in children is rare, often iatrogenic. Management focuses on rapid diagnosis, supportive care, antibiotics, nutrition, and restoring esophageal integrity, with nonoperative approaches common.
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Neonatal Care
Background:
- Esophageal perforation (EP) is a rare but serious condition.
- Iatrogenic causes are frequent in pediatric cases.
- Management differs significantly between pediatric and adult patients.
Purpose of the Study:
- To outline the key principles for managing pediatric esophageal perforation.
- To highlight the shift towards nonoperative treatment in neonates and children.
Main Methods:
- Review of current management strategies for pediatric EP.
- Emphasis on diagnostic and therapeutic interventions.
Main Results:
- Nonoperative management is a common and accepted approach in pediatric EP.
- Successful outcomes depend on rapid diagnosis and comprehensive supportive care.
Conclusions:
- Effective management of pediatric EP requires a multidisciplinary approach.
- Key components include hemodynamic support, antibiotics, nutritional support, and controlling contamination.
- Restoration of luminal integrity can be achieved nonoperatively or operatively.
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