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Published on: June 16, 2014
MoS2/TiO2/SiNW surface as an effective substrate for LDI-MS detection of glucose and glutathione in real samples
Abderrahmane Hamdi1, Ioana Silvia Hosu2, Ahmed Addad3
1Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, IEMN, UMR CNRS 8520, Avenue Poincaré, BP 60069, 59652 Villeneuve d'Ascq, France; Laboratory of Semi-conductors, Nano-structures and Advanced Technologies, Research and Technology Centre of Energy, Borj-Cedria Science and Technology Park, BP 95, 2050 Hammam-Lif, Tunisia; Faculty of Science of Bizerte, University of Carthage, 7021 Zarzouna, Tunisia; Institut de biologie de Lille, UMR CNRS 8160, 59000 Lille, France.
Abstract:
Here, we report for the first time, the use of molybdenum disulfide/titanium oxide/silicon nanowires (MoS2/TiO2/SiNW) surfaces for SALDI-MS detection as alternative to MALDI-MS method. Silicon nanowires were fabricated by the well-known metal-assisted chemical etching process followed by the deposition of TiO2 by atomic layer deposition. MoS2 deposition was achieved through hydrothermal treatment. The MoS2/TiO2/SiNW substrate has shown high performance for the detection of small compounds of different molecular weights, including glutathione, glucose, amino acids, antibiotics to name a few. All of the tested compounds, in pure or in mixed solutions were successfully detected in positive ion mode. Therefore, we have also attempted quantitative measurements of GSH and glucose in human blood serum.
