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Updated: Mar 1, 2026
Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications
Published on: April 28, 2015
Synthesis and characterization of a bimodal nanoparticle based on the host-guest self-assembly for targeted cellular
Huihui Wang1, Dongsheng Sun1, Han Liao1
1Stem Cell Group, Scientific Research Center for Translational Medicine, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, China; University of the Chinese Academy of Science, Beijing 100049, China.
Abstract:
Multimodal imaging provides distinct advantages over traditional single modal imaging. The combined modalities of magnetic resonance imaging (MRI) and near-infrared imaging (NIR), in particular, provide a powerful tool for tumor diagnosis. In this study, a bimodal MRI and NIR self-assembled supramolecular nanoparticle was developed via the self-assembly of host-guest interactions between hyaluronic acid-β-cyclodextrin (HA-CD) and amantadine (Ad)-modified imaging agents (Gd-DOTA and NIR cyanine dye Cy7). The supramolecular HA-CD-GC nanoparticles (NPs) were characterized by transmission electron microscopy (TEM), Zeta potential, and dynamic light-scattering (DLS) experiments. The relaxivity and fluorescent properties of the NPs were also determined. HA-CD-GC NPs exhibited an enhanced relaxivity of 11.4mM-1S-1, which was three-fold higher than that of clinical Gd3+-chelated complex, for MRI imaging. Moreover, HA-CD-GC NPs displayed excellent fluorescence. In addition, HA-CD-GC NPs were internalized into tumor cells via HA-receptor CD44-mediated endocytosis. Therefore, the self-assembled HA-CD-GC NPs are effective targeted tumor cell imaging systems and have potential applications in cancer diagnosis and treatment.
