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[Vitamin C+sodium bicarbonate versus sodium bicarbonate alone in preventing contrast-induced nephropathy]
L Laroussi1, M Triki1, Z Ibn Elhaj1
1Service de cardiologie, hôpital Abderrahmen Mami Ariana, Tunis, Tunisie.
Introduction:
Contrast-induced nephropathy (CIN) is a common and severe complication in interventional cardiology.
Objective:
The aim of our study was to compare the incidence of contrast-induced nephropathy in two accelerated hydration protocols: the first one by the serum bicarbonate and the second combining the serum bicarbonate and oral vitamin C.
Methods:
This is a multicenter prospective, randomized study conducted between October 2012 and May 2013, including 160 patients.
Results:
The mean age of our study population was 60.8±9.3 years (36-83 years). The two study groups were comparable in terms of cardiovascular risk factors, concomitant medication, and baseline serum creatinine. The CIN incidence was 6.3% in the vitamin C group and 10% in the control group (P=0.38). No significant difference was observed in terms of CIN incidence between the different subgroups analyzed.
Conclusion:
According to our study, ascorbic acid administered orally as part of an accelerated hydration protocol does not reduce the incidence of CIN.
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