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Serum chemerin in children with excess body weight may be associated with ongoing metabolic complications - A pilot

Marta Sledzińska1, Agnieszka Szlagatys-Sidorkiewicz1, Michał Brzezinski2

  • 1Department of Pediatrics, Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdansk, Poland.

Advances in Medical Sciences
|May 29, 2017
PubMed

Insights

Serum chemerin levels are higher in overweight children and correlate with obesity indicators and metabolic dysfunction. This suggests chemerin may signal early signs of inflammation and metabolic syndrome in pediatric patients.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Inflammation Markers

Background:

  • Obesity in children is a growing concern linked to metabolic complications.
  • Chemerin, an adipokine, is implicated in metabolic and inflammatory processes.
  • Understanding chemerin's role in pediatric obesity is crucial for early intervention.

Purpose of the Study:

  • To investigate the correlation between serum chemerin levels and anthropometric/metabolic parameters in children.
  • To assess chemerin as a potential biomarker for obesity-related inflammation and metabolic dysfunction in pediatric populations.

Main Methods:

  • Study included 101 children aged 5-17 years, categorized by BMI percentile (normal weight vs. overweight).
  • Serum chemerin concentrations were quantified using Enzyme-Linked Immunosorbent Assay (ELISA).
  • Correlations were analyzed with body weight, fat mass, inflammatory markers (CRP), liver function (ALT), and metabolic parameters (insulin, HOMA-IR).

Main Results:

  • Overweight children exhibited significantly elevated serum chemerin levels compared to normal-weight peers.
  • Serum chemerin showed positive correlations with body weight, BMI (absolute and percentile), and fat mass.
  • Significant positive associations were observed between chemerin and systolic blood pressure, CRP, ALT, insulin, and HOMA-IR.

Conclusions:

  • Elevated serum chemerin in overweight children may indicate obesity-related inflammation.
  • Chemerin could serve as an early marker for subclinical liver dysfunction and metabolic syndrome in pediatric obesity.
  • Serum chemerin warrants further investigation as a potential diagnostic tool in overweight pediatric patients.
Abstract

Keywords:
ChemerinMetabolic syndromeObesityOverweightSerum

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