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Updated: Mar 1, 2026
Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
Published on: December 5, 2020
Targeted Therapy in Ovarian Cancer. A Comprehensive Systematic Review of Literature
Yasser Diab1, Mustafa Zelal Muallem2
1Department of Gynecology, Portland District Hospital, Victoria, Australia.
Background/Aim:
We aimed to identify the most effectual groups of targeted therapies for ovarian cancer in recent clinical trials.
Materials And Methods:
A systematic literature review has been gathered on an inventive study design that comprises of five steps. This involves search for pertinent publications from 2010 to date in various accessible medical data bases, usage of inclusion and exclusion, appraisal of quality of the studies included, abstraction of the relevant data and intelligible amalgamation of the data abridged in an evocative and narrative style.
Results:
Three types of modalities of targeted-therapy drugs have been identified; angiogenesis inhibition, signal enzymes inhibition and apoptosis induction in the tumor cells.
Conclusion:
There has been a surge in clinical trials with drugs that specifically target signal enzymes, induce apoptosis and inhibit angiogenesis in site-specific ovarian cancer cells, which could be very promising to design a more efficacious protocol for treating the disease.
Insights
This review identifies key targeted therapy groups for ovarian cancer, including angiogenesis inhibitors, signal enzyme inhibitors, and apoptosis inducers. These show promise for developing more effective ovarian cancer treatment protocols.
Area of Science:
- Oncology
- Pharmacology
- Clinical Trials
Background:
- Ovarian cancer remains a significant health challenge.
- Identifying effective targeted therapies is crucial for improving patient outcomes.
Purpose of the Study:
- To identify the most effective groups of targeted therapies for ovarian cancer based on recent clinical trials.
- To synthesize current research on novel therapeutic strategies for ovarian cancer.
Main Methods:
- A systematic literature review was conducted.
- Publications from 2010 to the present were searched across medical databases.
- Study selection, quality appraisal, data abstraction, and narrative synthesis were performed.
Main Results:
- Three primary modalities of targeted therapies were identified: angiogenesis inhibition, signal enzyme inhibition, and apoptosis induction.
- Clinical trials are increasingly focusing on these targeted approaches in ovarian cancer.
Conclusions:
- Targeted therapies show significant promise for ovarian cancer treatment.
- Further research and clinical trials focusing on signal enzyme inhibition, apoptosis induction, and angiogenesis inhibition could lead to more efficacious treatment protocols.
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