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Updated: Mar 1, 2026

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The Immunological Roles of Periostin/Tumor-Associated Macrophage Axis in Development of Dermatofibrosarcoma

Taku Fujimura1, Aya Kakizaki2, Yota Sato2

  • 1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan tfujimura1@mac.com.

Anticancer Research
|May 29, 2017
PubMed
Abstract

Insights

Dermatofibrosarcoma protuberance (DFSP) involves periostin and tumor-associated macrophages (TAMs). Increased MMP1 and MMP12 in TAMs at DFSP

Area of Science:

  • Oncology
  • Dermatopathology
  • Cancer Biology

Background:

  • Dermatofibrosarcoma protuberance (DFSP) is a rare, slow-growing skin cancer with high recurrence rates.
  • Periostin, a protein involved in fibrosis and tumor growth, and tumor-associated macrophages (TAMs) are implicated in cancer stroma.
  • Understanding the roles of TAMs and matrix metalloproteinases (MMPs) in DFSP is crucial for targeted therapies.

Purpose of the Study:

  • To investigate the expression of periostin, TAM markers (CD163, CD206), and MMPs (MMP1, MMP12) in the tumor microenvironment of DFSP.
  • To correlate the presence of these factors with the invasive potential of DFSP.

Main Methods:

  • Immunohistochemical staining was performed on 10 DFSP and dermatofibroma tissue samples.
  • DNA microarray database analysis was utilized to identify relevant MMPs in macrophages.

Main Results:

  • DFSP tissues showed dense periostin deposits and numerous CD163+ TAMs, particularly at the tumor periphery.
  • MMP1 and MMP12 were detected in TAM-rich areas, correlating with findings from macrophage gene expression analysis.

Conclusions:

  • Elevated levels of MMP1 and MMP12 within TAMs at the periphery of DFSP tumors may facilitate local invasion.
  • Targeting periostin, TAMs, and specific MMPs could offer novel therapeutic strategies for managing DFSP recurrence.
Keywords:
DFSPMMP1MMP12periostintumor-associated macrophages

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