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Tissue Factor Expression Does Not Predict Mortality in Breast Cancer Patients.
Simon F Stämpfli1,2, Alexander Akhmedov1, Silke Hausladen3
1Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
Anticancer Research
|May 29, 2017
Summary
Tissue factor (TF) is highly expressed in breast cancer, correlating with estrogen receptor status and inversely with tumor grade. However, this study found no evidence that TF expression impacts patient survival.
Area of Science:
- Oncology
- Hematology
- Molecular Biology
Background:
- Tissue factor (TF) initiates coagulation and is implicated in breast cancer growth and invasion.
- The precise role and prognostic significance of TF in breast cancer remain incompletely understood.
Purpose of the Study:
- To characterize TF expression in breast cancer tissues.
- To evaluate the prognostic value of TF expression in breast cancer patients.
Main Methods:
- Immunohistochemical analysis of TF expression in 303 primary breast cancer specimens.
- Correlation of TF expression with tumor characteristics (size, grade, nodal status, ER expression) and patient survival.
Main Results:
- TF expression was detected in 99% of breast cancer specimens.
- Higher TF expression was observed in invasive lobular carcinoma compared to ductal carcinoma (p=0.008).
- TF expression correlated positively with estrogen receptor (ER) expression (p<0.0001) and inversely with tumor grade (p=0.006).
Conclusions:
- TF is ubiquitously expressed in breast cancer.
- TF expression is associated with specific tumor characteristics but does not appear to have prognostic value.
- This large-scale analysis does not support TF expression as a prognostic marker in breast cancer.
