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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Induced Pluripotent Stem Cells01:13

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Mar 1, 2026

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Modelling Autistic Neurons with Induced Pluripotent Stem Cells.

Annie Kathuria1,2, Carlo Sala3, Chiara Verpelli4

  • 1Centre for Stem Cells and Regenerative Medicine, King's College, London, UK.

Advances in Anatomy, Embryology, and Cell Biology
|May 29, 2017
PubMed
Summary

Autism spectrum disorder (ASD) research uses induced pluripotent stem cells (iPSCs) to model neurodevelopmental conditions. This review explores iPSC models for understanding ASD heterogeneity and co-occurring diseases.

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Genetics

Background:

  • Autism spectrum disorder (ASD) is a complex neurodevelopmental condition affecting over 1% of children, characterized by social-communication deficits and restricted behaviors.
  • Current treatment limitations stem from clinical/genetic heterogeneity and poorly understood pathophysiological mechanisms.
  • Induced pluripotent stem cells (iPSCs), derived from adult cells, offer a powerful tool for studying human cellular phenotypes.

Purpose of the Study:

  • To systematically review the application of human iPSCs in modeling various autism spectrum disorder (ASD) variants.
  • To explore how iPSC-derived models contribute to understanding the cellular and molecular underpinnings of ASD.
  • To examine the use of iPSCs in modeling diseases co-occurring with ASD.

Main Methods:

  • Systematic literature review of studies utilizing human induced pluripotent stem cells (iPSCs) for autism spectrum disorder (ASD) modeling.
  • Analysis of research focusing on cellular and molecular phenotypes derived from iPSC lines of individuals with ASD.
  • Inclusion of studies investigating ASD-associated genetic variants and co-morbid conditions within iPSC models.

Main Results:

  • Human iPSCs enable the recapitulation of specific cellular and molecular phenotypes relevant to ASD.
  • iPSC-based models facilitate the investigation of genetic heterogeneity and its impact on ASD pathology.
  • The use of iPSCs aids in studying complex interactions between ASD and co-morbid conditions at a cellular level.

Conclusions:

  • Human iPSCs provide a valuable platform for dissecting the complex pathophysiology of autism spectrum disorder (ASD).
  • iPSC technology is crucial for advancing research into ASD variants and associated co-morbidities.
  • Further utilization of iPSC models promises to uncover novel therapeutic targets for ASD.