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Updated: Mar 1, 2026

Analyzing Multifactorial RNA-Seq Experiments with DiCoExpress
Published on: July 29, 2022
3D clustering of co-regulated genes and its effect on gene expression
1Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, State College, PA, USA.
Abstract:
There are extensive long-distance chromosomal interactions in eukaryotic genomes, but to what extent these interactions affect gene expression is not clear. Recent works have identified several cases where clustering of co-regulated genes leads to enhanced gene expression in budding yeast. Similar phenomenon was also observed in mammalian cells. These results challenge widely held views of gene regulation in yeast and further our understanding of how the 3D organization of the genome contribute to gene regulation in eukaryotes.
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