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Detection of microRNA Expression in Peritoneal Membrane of Rats Using Quantitative Real-time PCR
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CD147 expression in peritoneal injury.

Harald Seeger1,2, Joerg Latus3, Daniel Kitterer3

  • 1Division of Nephrology, University Hospital, Rämistr. 100, 8091, Zurich, Switzerland.

Clinical and Experimental Nephrology
|May 29, 2017
PubMed
Summary
This summary is machine-generated.

CD147, a glycoprotein, is significantly elevated in patients with encapsulating peritoneal sclerosis (EPS), a severe complication of peritoneal dialysis (PD). This finding highlights CD147

Keywords:
CD147EPSEmmprinEncapsulating peritoneal sclerosisPeritoneal dialysis

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Area of Science:

  • Nephrology
  • Cell Biology
  • Immunology

Background:

  • Peritoneal dialysis (PD) is crucial for end-stage renal disease management but can lead to peritoneal injury and encapsulating peritoneal sclerosis (EPS).
  • CD147, a glycoprotein, influences extracellular matrix, cell adhesion, and immune responses, suggesting a potential role in peritoneal complications.
  • Understanding the molecular mechanisms of EPS is vital for improving long-term PD outcomes.

Purpose of the Study:

  • To investigate the expression and localization of CD147 in the peritoneal tissue of patients undergoing long-term PD.
  • To determine the association of CD147 expression with the development of encapsulating peritoneal sclerosis (EPS).
  • To explore the cellular source of CD147 in EPS using co-localization studies.

Main Methods:

  • Retrospective analysis of peritoneal biopsies from uremic patients without PD, PD patients without EPS, and PD patients with EPS.
  • Immunohistochemistry was employed to localize CD147 expression in peritoneal tissues.
  • Double immunofluorescence was used to co-localize CD147 with alpha-smooth muscle actin (α-SMA) positive myofibroblasts.

Main Results:

  • CD147 was expressed in mesothelial cells, perivascular cells, and between fat cells in controls.
  • In EPS biopsies, CD147 was prominently expressed on fibroblastic cells, which were identified as α-SMA positive myofibroblasts.
  • EPS biopsies showed significantly higher CD147 expression scores compared to uremic controls.

Conclusions:

  • This study provides the first evidence of significant CD147 expression on myofibroblasts in encapsulating peritoneal sclerosis.
  • The findings suggest CD147 may play a role in the pathogenesis of EPS.
  • Further research is warranted to elucidate the specific functions of CD147 in this severe PD complication.