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Related Experiment Video

Updated: Mar 1, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
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[DYNAMIC CHANGES OF D-DIMER FOLLOWING STROKE].

Lihi Shapir1, Bella Gross2,3

  • 1Department of Family Medicine, Technion, Clalit Health Services, Haifa and Western Galilee.

Harefuah
|May 29, 2017
PubMed
Summary
This summary is machine-generated.

Plasma D-dimer levels correlate with stroke type, severity, and mortality. Elevated D-dimer after stroke indicates higher complication risk and poorer outcomes, aiding in prognosis.

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Area of Science:

  • Neurology
  • Hematology
  • Biomarkers

Background:

  • D-dimer, a fibrin degradation product, is elevated in systemic vascular events.
  • The precise relationship between plasma D-dimer levels and stroke outcomes remains unclear.
  • Investigating D-dimer's role in stroke is crucial for understanding disease mechanisms and prognosis.

Purpose of the Study:

  • To determine the correlation between plasma D-dimer levels and stroke etiology.
  • To assess the relationship between D-dimer levels and stroke severity.
  • To evaluate D-dimer as a potential prognostic factor for stroke complications and mortality.

Main Methods:

  • 96 acute stroke patients were enrolled.
  • Plasma D-dimer levels were measured at multiple time points: admission, 24 hours, 1 week, and 3 months post-stroke.
  • Stroke severity and type were assessed using the NIH Stroke Scale (NIHSS) and brain CT scans.

Main Results:

  • Plasma D-dimer levels were elevated post-stroke, normalizing by 3 months.
  • Highest D-dimer levels were observed in patients with intracerebral hemorrhage (ICH), lowest in those with normal CT scans.
  • Significant correlations were found between D-dimer levels and stroke severity (p=0.039), and between high D-dimer levels and mortality (P=0.017).

Conclusions:

  • Plasma D-dimer levels are associated with stroke etiology, lesion size, and acute stroke severity.
  • Elevated D-dimer levels post-stroke are linked to increased early complications and higher mortality rates.
  • D-dimer shows potential as a prognostic biomarker for adverse outcomes in acute stroke patients.