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Related Experiment Video

Updated: Mar 1, 2026

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
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[ABO INCOMPATIBLE KIDNEY TRANSPLANTATION].

Sigal Eisner1, Jacob Orlin2, Eviatar Nesher1

  • 1Department of Transplantation, Rabin Medical Center, Beilinson Hospital, Petach-Tikva, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Israel.

Harefuah
|May 29, 2017
PubMed
Summary
This summary is machine-generated.

ABO incompatible kidney transplants show excellent graft and patient survival rates, comparable to ABO compatible transplants. Close monitoring is crucial to prevent antibody-mediated rejection after ABO incompatible procedures.

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Area of Science:

  • Nephrology
  • Transplant Surgery
  • Immunology

Background:

  • Advancements in therapies have enabled ABO incompatible (ABOi) kidney transplantation.
  • Recent outcomes suggest ABOi kidney transplantation results are comparable to ABO compatible transplantation.
  • This study reports initial experiences with ABOi kidney transplantation at Rabin Medical Center.

Purpose of the Study:

  • To evaluate the efficacy and safety of ABO incompatible kidney transplantation.
  • To compare graft and patient survival, antibody-mediated rejection (AMR), and graft function between ABOi and ABO-matched kidney transplant recipients.
  • To assess the feasibility of ABOi kidney transplantation as an alternative option.

Main Methods:

  • A cohort of 22 patients with 0% PRA undergoing ABOi living-donor kidney transplantation was compared to 325 non-sensitized ABO-matched live-donor transplant recipients.
  • The desensitization protocol involved rituximab, plasmapheresis, and intravenous immunoglobulin (IVIG).
  • Key outcomes measured included graft survival, patient survival, AMR incidence, and graft function (creatinine levels).

Main Results:

  • Graft survival rates at 1, 3, and 5 years were 95.5% for ABOi and 97.9% for ABO-matched transplants (not significant).
  • Patient survival rates were 100% at all intervals for ABOi recipients and 97.5% at 5 years for ABO-matched recipients (not significant).
  • AMR occurred in 9.1% of ABOi recipients versus 0.85% of ABO-matched recipients (p<0.05); graft function was comparable.

Conclusions:

  • ABO incompatible kidney transplantation is a viable option offering excellent outcomes.
  • Rigorous monitoring of antibody levels post-transplant is essential for early detection and management of AMR.
  • ABOi transplantation expands options for patients requiring kidney transplants.