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Zika Virus Infectious Cell Culture System and the In Vitro Prophylactic Effect of Interferons
Published on: August 23, 2016
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Advances in research on Zika virus
Amjad Ali1, Braira Wahid1, Shazia Rafique1
1Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan.
Asian Pacific Journal of Tropical Medicine
|May 30, 2017
Summary
Zika virus (ZIKV) poses a significant threat, especially to pregnant women and infants. Research is advancing rapidly, with promising developments in vaccines and antiviral drugs to combat ZIKV outbreaks.
Area of Science:
- Virology
- Epidemiology
- Vaccinology
Background:
- Zika virus (ZIKV) has emerged as a significant global health concern, particularly due to its devastating effects on pregnant women and infants.
- Recent outbreaks in the Pacific and the Americas highlight the urgent need for effective countermeasures against ZIKV.
Purpose of the Study:
- To review the latest research strategies for developing ZIKV vaccines and antiviral drugs.
- To explore the molecular evolution, epidemiology, neurological complications, and teratogenic outcomes associated with ZIKV.
Main Methods:
- Review of current scientific literature on ZIKV research.
- Analysis of data on vaccine platforms, antiviral drug development, and clinical trials.
Main Results:
- Multiple vaccine platforms (DNA, recombinant subunit, inactivated, chimeric) show promise in preclinical trials.
- Several antiviral drugs (Sofosbuvir, BCX4450, NITD008, 7-DMA) are advancing to clinical trials.
- Monoclonal antibodies present a potential intervention for pregnant women.
Conclusions:
- Significant progress has been made in developing ZIKV vaccines and antiviral therapies.
- Continued research is crucial to address the global threat of ZIKV, including its neurological and teratogenic effects.
