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Articles linked to this work by shared authors, journal, and citation graph.

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Related Experiment Video

Updated: Mar 1, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

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Sterile infiltrates after cross-linking.

G García de Oteyza1, J Álvarez de Toledo1

  • 1Servicio de Córnea y Segmento Anterior, Centro de Oftalmología Barraquer, Barcelona, España.

Archivos De La Sociedad Espanola De Oftalmologia
|May 30, 2017
PubMed
Summary

Corneal cross-linking is a safe procedure for keratoconus, but sterile infiltrates can occur post-operation. This case highlights a rare complication, emphasizing the need for further research into its causes.

Keywords:
ComplicaciónComplicationCross-linkingInfiltrados estérilesKeratoconusQueratoconoSterile infiltrates

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Last Updated: Mar 1, 2026

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Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Biomaterials Science

Background:

  • Keratoconus is a progressive thinning of the cornea, leading to irregular astigmatism and vision loss.
  • Corneal cross-linking (CXL) is a standard treatment to halt keratoconus progression by strengthening corneal tissue.
  • Asymmetric bilateral keratoconus requires careful consideration for treatment, balancing efficacy with potential risks.

Observation:

  • A 20-year-old female patient with asymmetric bilateral keratoconus underwent CXL in her right eye.
  • Post-procedure monitoring revealed the development of corneal infiltrates within three days.
  • These infiltrates were clinically assessed and classified as sterile, lacking signs of active infection.

Findings:

  • The case report documents the occurrence of sterile infiltrates following standard CXL procedure.
  • While CXL is generally safe, this observation points to potential, albeit rare, complications.
  • The etiology of these sterile infiltrates remains unclear, necessitating further investigation.

Implications:

  • This case underscores the importance of vigilant post-operative monitoring after CXL.
  • Understanding the causes of sterile infiltrates could refine CXL protocols and patient selection.
  • Further research is warranted to elucidate the pathogenesis of sterile infiltrates and optimize patient outcomes in keratoconus management.